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KMID : 1103720090610050279
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Journal of the Korean Society of Radiology
2009 Volume.61 No. 5 p.279 ~ p.289
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Using fMRI to Detect Activation of the Cortical and Subcortical Auditory Centers: Development of a Standard Protocol for a Conventional 1.5-T MRI Scanner
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Tae Woo-Suk
Kim Sam-Soo
Lee Kang-Uk
Lee Seung-Hwan
Choi Hyun-Kyung
Nam Eui-Cheol
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Abstract
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Purpose: We wanted to develop a standard protocol for auditory functional magnetic resonance imaging (fMRI) for detecting blood oxygenation level-dependent (BOLD) responses at the cortical and subcortical auditory centers with using a 1.5-T MRI scanner.
Materials and Methods: Fourteen normal volunteers were enrolled in the study. The subjects were stimulated by four repetitions of 32 sec each with broadband white noise and silent period blocks as a run (34 echo planar images [EPIs]). Multiple regression analysis for the individual analysis and one-sample t-tests for the group analysis were applied (FDR, p <0.05).
Results: The auditory cortex was activated in most of the volunteers (left 100% and right 92.9% at an uncorrected p value <0.05, and left 92.9% and right 92.9% at an uncorreced p value <0.01). The cochlear nuclei (100%, 85.7%), inferior colliculi (71.4%, 64.3%), medial geniculate bodies (64.3%, 35.7%) and superior olivary complexes (35.7%, 35.7%) showed significant BOLD responses at uncorrected p values of <0.05 and p <0.01, respectively. On the group analysis, the cortical and subcortical auditory centers showed significant BOLD responses (FDR, p <0.05), except for the superior olivary complex. The signal intensity time courses of the auditory centers showed biphasic wave forms.
Conclusion: We successfully visualized BOLD responses at the cortical and subcortical auditory centers using appropriate sound stimuli and an image acquisition method with a 1.5-T MRI scanner.
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KEYWORD
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Brain, Magnetic resonance (MR), Echo-planar imaging, Auditory pathways
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